
MAXODERM™,
How Does It Work In Your Body?
Sexual
arousal results in excitatory signals to the nervous system resulting in a
release of nitric oxide in the corpus cavernosum (i.e., spongy erectile
tissue of the penis). Nitric oxide diffuses into the smooth muscle cells
lining the arteries of the corpus cavernosum, thereby relaxing vascular and
trabecular smooth muscle cells. The relaxation of the smooth muscles lining
the penile arteries allows these arteries of the corpus cavernosum to become
engorged with blood, compressing the veins that drain blood from the penis
and, as a result, trapping blood within the corpus cavernosum to produce an
erection.
The physiology of the male erectile tissue provides
numerous points of interaction in which nervous or chemical manipulation may
be used to overcome sexual dysfunction or enhance sexual responsiveness.
For instance, commercially successful prescription drugs
designed to interact with biochemistry of this system to treat erectile
dysfunction include potent inhibitors of phosphodieterase type 5 enzymes
(such as sildenafil), which function to prevent the ensuing subsidence of
the corpus cavernosum.
Maxoderm™,
on the other hand, is aimed at taking advantage of the increased production
of nitric oxide.
Nitric Oxide And
L-arginine Connection
Research has shown that the administration of L-arginine is
another means of manipulating the biochemistry of the erectile processes to
produce a greater nitric oxide-medicated erectile response. Nitric oxide is
synthesized from L-arginine by nitric oxide synthase. The enzyme arginase
regulates the L-arginine bioavailability to nitric oxide synthase by
hydrolyzing L-arginine, thereby depleting the intracellular pool of L-arginine
available to form nitric oxide. Therefore, the administration of L-arginine,
arginase inhibitors and stimulants of nitric oxide synthase production have
been used to enhance male sexual response and to treat sexual dysfunction in
males through the enhanced production of nitric oxide. Of these treatments,
the administration of L-arginine has been the most extensively studied and
successful.
We also know the administration of L-arginine is
very effective in
increasing the blood in erectile tissue leading to
increased sexual arousal. These effects are mediated through the nitric
oxide pathway by the increased intracellular supply of L-arginine available
for conversion of nitric oxide.
Source and
more information:
Reference Links:
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